How Prizmah Works
Prizmah promotes & accelerates the healing with improvement in symptoms, significant redution in pain.
Growth Factors
The rationale for the widespread use of PRP in multiple medical specialties resides in the fact that platelets represent an easily accessible reservoir of critical growth factors and other signaling molecules, including leukocyte derived catabolic cytokines and fibrinogen.
The degranulation of platelets released growth factors and bioactive proteins from alpha granules, which are responsible for attracting macrophages and mesenchymal stem cells and may govern and regulate the tissue-healing process.
Skin aging is a continuous process which can be accelerated by genetics, facial expressions and extrinsic factors like a poor diet, smoking and sun exposure. These all cause oxidative stress, a key component of the aging process, that appears as fine lines, hyperpigmentation, unevenness of skin tone, sagging skin and advanced wrinkling.
Prizmah is a form of bio-stimulator that is safe and creates an immediate, long lasting volumetric effect with natural looking results. Prizmah offers following advantages:
- Prizmah is used for stimulation of both superficial and deep dermis layers.
- Prizmah must be injected into the deep dermis or subdermal tissues when using as filler.
- The superficial injection might be done by mesotherapy technique in order to improve the skin texture, elasticity and hydration.
Platelet
- 250,000 – 500,000 (approx.) / mm3
- Platelets excrete growth factors also called “Cytokines” & are proteins
- They are stored in the Alpha-Granules in platelets
- In response to platelet to platelet aggregation or platelet to connective tissue contact, or fibrin thread formation, as occurs in injury or surgery, the cell membrane of platelet is “activated” to release growth factors from alpha-granules
Prizmah Preparation Steps
Schemetic diagram of activated PRP with mode of action
Growth factors & proteins in Prizmah PRP
- Exhibits technically advanced gel separator which removes almost all of the RBCs & WBCs in the PRP thus produces pure PRP (no need of filtration).
- Offers high platelet concentration in PRP thus accelerates the healing process & reduces the pain.
- Easy to use, takes less time, requires less blood and is not user dependent like other systems.
- In Prizmah, blood and PRP are not exposed to air/oxygen during the process, i.e. Biocom- patible & Xeno Free Closed System.
- The anticoagulant in Prizmah is sodium citrate which has a close to physiologic pH (7.4), thus no burning pain during & after PRP injection.
- Offers complete system of activation of PRP results in degranulation of platelets to sustained release of growth factors and bioactive proteins from alpha-granules.
- Reduces the need of pain management medication, steroid injections or surgery etc.