Wound Management
Prizmah promotes & accelerates the healing with improvement in symptoms, significant redution in pain.
Wound healing is a complex process mediated by interacting molecular signals involving mediators and cellular events. Platelets play two important roles in wound healing, hemostasis and initiation of wound healing. Autolo-gous growth factors from concentrated platelet suspensions have been used to treat chronic wounds for more than 25 years.
Prizmah is a bio-stimulator that is safe and heals the wound naturally. By application of Prizmah, wound healing time can be reduced significantly.
- Prizmah curbs inflammation by suppressing cytokine release, and further improve the regeneration process by promoting capillary angiogenesis and re-epithelialization.
- The collaboration of the macrophages in the healing process is also initiated when they are called into action by platelet excretion of signaling proteins
- Prizmah promotes ECM synthesis, collagen production and stem cells proliferation & differentiation.
Mechanism of Wound Healing
PRP is safe, simple and effective procedure in treating chronic venous ulcers.
( Cutan Aesthet Surg. 2013 Apr; 6(2): 97-9)
PRP can be used for the treatment of wounds of all types including burns and also of split-thickness skin graft donor sites, which are frequently used in burn management.
(Annals of Burns and Fire Disasters – vol. XXV – n. 4 – December 2012)
This study has shown that PRP gel treatment can be a valuable and effective aid in the management of acute trauma wounds.
(Injury. 2008.05.002)
When used with good standards of care, the majority of nonhealing diabetic foot ulcers treated with autologous platelet-rich plasma gel can be expected to heal.
(Ostomy Wound Management 2006 Jun;52(6):68-70)
Platelet concentrates may be potentially useful in wound healing applications because they function as both a tissue sealant and a delivery system that contains a variety of
mitogenic and chemotactic growth factors. U Diabetes Sci Technol. 2010 Sep; 4(5): 1121-1126.)
Prizmah Preperation Steps
Schemetic diagram of activated PRP with mode of action
Growth factors & proteins in Prizmah PRP
Stages & Time Duration of Wound Healing
- Exhibits technically advanced gel separator which removes almost all of the RBCs & WBCs in the PRP thus produces pure PRP (no need of filtration).
- Offers high platelet concentration in PRP thus accelerates the healing process & reduces the pain.
- Easy to use, takes less time, requires less blood and is not user dependent like other systems.
- In Prizmah, blood and PRP are not exposed to air/oxygen during the process, i.e. Biocom- patible & Xeno Free Closed System.
- The anticoagulant in Prizmah is sodium citrate which has a close to physiologic pH (7.4), thus no burning pain during & after PRP injection.
- Offers complete system of activation of PRP results in degranulation of platelets to sustained release of growth factors and bioactive proteins from alpha-granules.
- Reduces the need of pain management medication, steroid injections or surgery etc.