Question 1

What is PRP therapy?

Accepted Answer

Platelet-Rich Plasma (PRP) is derived from the patient's own blood. Processing separates the blood components and concentrates platelets rich in growth factors and bioactive proteins. These initiate tissue repair, accelerate regeneration, increase stem-cell production, promote new blood-vessel development and stimulate wound healing.

Question 2

What is the difference between PRP and PRF?

Accepted Answer

PRP results from centrifuging blood to concentrate platelets. When an activator such as calcium chloride is added to PRP, fibrin threads begin to appear as a matrix or net — creating Platelet-Rich Fibrin (PRF), in which the platelets are activated and held at the site.

Question 3

What are the benefits of PRF over PRP?

Accepted Answer

In PRP the platelets remain inactive and may migrate from the injection site. In PRF the platelets become activated through calcium chloride, and the fibrin matrix holds them firmly at the site of injection — so growth factors are released at the desired area over a longer period of time.

Question 4

What are the functions of the important growth factors in PRF?

Accepted Answer

PDGF supports cell growth, blood-vessel repair and collagen production; FGF drives tissue repair, cell growth and collagen production; VEGF promotes vascular cell growth; EGF supports epithelial cell growth and wound healing; TGF-β promotes wound healing; and IGF regulates cell growth.

Question 5

How is Prizmah different from other PRP kits?

Accepted Answer

Prizmah removes RBCs and WBCs, reducing hemosiderin staining and inflammation. It has built-in calcium chloride in exactly the right concentration to initiate fibrin polymerization, requires less blood, takes less time, uses a closed system, and contains sodium citrate to maintain physiologic pH.

Question 6

Explain the procedure to obtain PRF from Prizmah.

Accepted Answer

Draw 9cc of blood into the tube; centrifuge for 6 minutes at 1100g; transfer the PRP to the activation tube containing calcium chloride; rotate gently 3–4 times; and inject within 20–25 minutes, before the PRF becomes too viscous.

Question 7

What should be considered while centrifuging to obtain PRP?

Accepted Answer

Ensure the lid is properly latched with the yellow indicator illuminated. Place the centrifuge on a level, flat, hard surface. The centrifuge must contain a balanced load — opposing tube holders must match with equal weights. Centrifuge for 6 minutes and repeat if separation is improper.

Question 8

How does PRF work?

Accepted Answer

Platelets migrate to injury sites as first responders, releasing factors that initiate tissue regeneration, promote blood-vessel development and stop bleeding. Alpha granules contain the clotting and growth factors released during healing, and calcium chloride triggers platelet activation.

Question 9

What are the advantages of PRF therapy?

Accepted Answer

Applications include facial rejuvenation addressing fine lines, wrinkles, acne scars, saggy skin, eye bags, neck wrinkles, stretch marks, hand rejuvenation and hair growth. Benefits include increased collagen and elastin production and extracellular-matrix formation.

Question 10

What does a Prizmah box contain?

Accepted Answer

Each sterile-packaged box includes a safety butterfly blood-collection set, a specialised 9cc blood-collecting tube with thixotropic separator gel and sodium citrate, a closed-system jacketed device, an activation tube with calcium chloride, and a PRP collection tube that preserves PRP for 4 hours at 3–4°C.

Question 11

Is Prizmah safe?

Accepted Answer

Prizmah is a very safe PRP kit. It does not contain animal or foreign components, so there is no risk of an allergic or adverse reaction. Reports show zero granulomas or nodules.

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